Journal article
O. Yavuz, A. Aksoy, Y. K. Das, M. Y. Gulbahar, D. Guvenc, E. Atmaca, Fatma Gul Yarim, M. Çenesiz
Toxicology and industrial health, 2015
Toxicology and industrial health, 2015
Semantic Scholar
DOI
PubMed
Cite
Cite
APA
Click to copy
Yavuz, O., Aksoy, A., Das, Y. K., Gulbahar, M. Y., Guvenc, D., Atmaca, E., … Çenesiz, M. (2015). Subacute oral toxicity of combinations of selected synthetic pyrethroids, piperonyl butoxide, and tetramethrin in rats. Toxicology and Industrial Health.
Chicago/Turabian
Click to copy
Yavuz, O., A. Aksoy, Y. K. Das, M. Y. Gulbahar, D. Guvenc, E. Atmaca, Fatma Gul Yarim, and M. Çenesiz. “Subacute Oral Toxicity of Combinations of Selected Synthetic Pyrethroids, Piperonyl Butoxide, and Tetramethrin in Rats.” Toxicology and industrial health (2015).
MLA
Click to copy
Yavuz, O., et al. “Subacute Oral Toxicity of Combinations of Selected Synthetic Pyrethroids, Piperonyl Butoxide, and Tetramethrin in Rats.” Toxicology and Industrial Health, 2015.
BibTeX Click to copy
@article{o2015a,
title = {Subacute oral toxicity of combinations of selected synthetic pyrethroids, piperonyl butoxide, and tetramethrin in rats},
year = {2015},
journal = {Toxicology and industrial health},
author = {Yavuz, O. and Aksoy, A. and Das, Y. K. and Gulbahar, M. Y. and Guvenc, D. and Atmaca, E. and Yarim, Fatma Gul and Çenesiz, M.}
}
Abstract
In this study, 70 Wistar rats were randomly divided into seven equal groups (six experimental and one control), which consisted of animals belonging to both sexes. Different combinations of insecticides were administered daily to the experimental groups (group 1: cypermethrin + piperonyl butoxide (PBO); group 2: alphacypermethrin + PBO; group 3: deltamethrin + PBO; group 4: cypermethrin + PBO + tetramethrin; group 5: alphacypermethrin + PBO + tetramethrin; and group 6: deltamethrin + PBO + tetramethrin) for 28 days. During the study period, mortality and serious clinical findings were not observed in any animal. However, feed consumptions decreased in groups 1 and 3 (p < 0.05). Red blood cells, white blood cells, and hemoglobin levels, especially in cypermethrin and alphacypermethrin groups (groups 1, 2, and 4), were found to be higher than the control group (p < 0.05). Furthermore, biochemical changes related to liver, kidney functions, and protein metabolism occurred in males of almost all the groups. Relative liver and kidney weights of the male animals increased in the cypermethrin and alphacypermethrin groups (p < 0.05). The most common finding observed during the histopathological examination of all the experimental groups was centrilobular degeneration in the liver. It was concluded that although clinical symptoms were not observed, synthetic pyrethroid, synergist, and knockdown agent combinations might cause serious abnormalities when administered in certain doses in mammalians.